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Thus, this sample showed relatively intact verbal abilities (although perhaps even lower than premorbid abilities), but severely affected visual motor and processing speed skills, as well as deficits in visual spatial ability, and either short-term memory or sequential processing skills Performance Deficits in Parkinson s Disease The Psychological Corporation (1997) also reported WAIS-III data for a small sample of 10 patients with Parkinson s disease (mean age = 712, 80% male, 80% Caucasian), a disease of involuntary movement characterized by resting tremors, reduced initiation of voluntary movements, shuffling gait, plastic rigidity, and impaired posture (p 152) Like MS, one would hypothesize V > P profiles for patients with Parkinson s disease, and, indeed, they had a 123-point discrepancy Their index profile, though not as extreme as the MS sample concerning the PSI, was as follows: VCI (969) > WMI (896) > POI (84.

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7) > PSI (817) In addition to studying Huntington s patients (and patients with Alzheimer s disease), Randolph et al (1993) obtained WAIS-R data on 59 patients with Parkinson s Disease (mean age 46), demonstrating a V > P IQ discrepancy of.

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14.9 points, similar to the value reported for the small WAIS-III sample of patients with Parkinson s disease.

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General intellectual deterioration is one of the hallmarks of individuals with Alzheimer s disease, but the cognitive deficiencies are complex. Memory impairment (both in learning new information and recalling old information) is part of the diagnostic criteria (American Psychiatric Association, 1994). Nonverbal measures appear to be affected to a greater extent than are verbal measures, commonly leading to a Wechsler profile of V > P. The V > P Profile Fuld (1984) was able to obtain valid WAIS data for 46 Alzheimer s patients; based on IQs prorated from four Verbal and three Performance subtests, she observed V > P profiles of 15 or more points in 24 (52%) of these patients. Intriguingly, Fuld also obtained dramatic V > P findings for 20 normal graduate and undergraduate students who were given drugs to induce experimentally the impaired cholinergic neurotransmitter functioning believed to characterize Alzheimer s patients. All 20 subjects demonstrated V > P patterns, with 15 (75%) showing differences of at least 15 points. To ensure that the V > P profile did not merely reflect the high educational attainment of the sample, Fuld administered placebos to a control group of 22 medical and undergraduate students. This group also tended to have higher Verbal IQs (16 individuals, or 73%, had V > P), but only 18% of the control subjects had a Verbal superiority by 15 or more points. Brinkman and Braun (1984) also identified a WAIS V > P pattern in their sample of 23 adults suspected of Alzheimer s-type dementia. This group scored 7 points higher on the Verbal Scale (IQs of 97 and 90). However, it is unclear whether the V > P pattern that seems to be associated with Alzheimer s disease is useful in differentiating Alzheimer s patients from those with

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other types of dementia In Brinkman and Braun s investigation, the 39 patients with multiinfarct dementia clearly did not evidence a substantial V > P pattern (V-IQ = 95, P-IQ = 94) However, Fuld (1984) found that 7 of her 11 multi-infarct dementia patients (64%) showed a V > P profile of 15+ points, very similar to the value of 52% obtained for the patients with Alzheimer s-type dementia Randolph et al (1993) examined the WAIS-R scores of 53 patients with Alzheimer s disease (mean age 66), in addition to the samples of patients with Huntington s disease and Parkinson s disease, discussed previously The patients with Alzheimer s disease and Huntington s disease were not significantly different in their global IQs, but the Parkinson s group IQ means were significantly higher than both the Alzheimer s and Huntington s groups Randolph et al.

s results showed that all three groups had a V > P pattern; Alzheimer s patients had a mean V P discrepancy of 82 points, a bit larger than the discrepancy for Huntington s patients, but considerably smaller than the V > P profile for Parkinson s patients Overall, all three samples of patients with dementia were characterized by preservation of verbal knowledge and relative impairment on the Performance subtests, and, generally, the subtest profiles were remarkably similar Like the similarities found between dementing diseases such as Alzheimer s, Huntington s, and Parkinson s (Randolph et al, 1993), there are also many similarities between Alzheimer s-type dementia and multi-infarct dementia In the early stages of both of these disorders, there are cognitive deficits, but some of the cognitive differences include greater impairment in abstract thinking and judgment for patients with Alzheimer s disease.

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